Pierre de Manchicourt (c. 1510 – 5 October 1564) was a Renaissance composer of the Franco-Flemish School.

De Manchicourt was born at Béthune. Little is known of his early life other than that he was a choirboy at Arras in 1525; later in life he had a succession of posts in Arras, Tours and Tournai, before going to Spain to be master of the Flemish chapel (capilla flamenca) at the court of Philip II, where he stayed for the remainder of his life.

Manchicourt is an excellent example of a Franco-Flemish composer who learned his craft and art in northern Europe, and then assisted in the diffusion of the style by traveling to another region and composing and performing there. The movement of these many skilled composers out of Flanders and northern France created what was one of the first truly international styles since the original diffusion of Gregorian chant during the reign of Charlemagne.

He died in Madrid and was succeeded as maestro de capilla by Jean de Bonmarché.